For research use only, not for therapeutic use.
<p>
Wedelolactone (CAS 524-12-9)<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;"> </span></span><span style="font-family: arial, helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">is an Irreversible inhibitor of IKKα and β kinase activity (IC</span><sub style="font-size: 10px; line-height: 14px; color: rgb(102, 94, 88); font-family: Arial, Helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">50</sub><span style="font-family: arial, helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;"> < 10 μM). It </span><span style="font-family: arial, helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. </span><span style="font-family: arial, helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">Wedelolactone has no effects on p38 MAP kinase or Akt.</span></p>
| Catalog Number | R006650 |
| CAS Number | 524-12-9 |
| Synonyms | 1,8,9-trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one |
| Molecular Formula | C16H10O7 |
| Purity | ≥95% |
| Target | IκB/IKK |
| IUPAC Name | 1,8,9-trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one |
| InChI | InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3 |
| InChIKey | XQDCKJKKMFWXGB-UHFFFAOYSA-N |
| SMILES | COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O |
| Reference | <div style="orphans: auto; widows: auto;"> |
