Wedelolactone

For research use only, not for therapeutic use.

  • CAT Number: R006650
  • CAS Number: 524-12-9
  • Molecular Formula: C16H10O7
  • Molecular Weight: 314.249
  • Purity: ≥95%
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<p>
Wedelolactone (CAS&nbsp;524-12-9)<span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">&nbsp;</span></span><span style="font-family: arial, helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">is an Irreversible inhibitor of IKK&alpha; and &beta; kinase activity (IC</span><sub style="font-size: 10px; line-height: 14px; color: rgb(102, 94, 88); font-family: Arial, Helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">50</sub><span style="font-family: arial, helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;&lt; 10 &mu;M). It&nbsp;</span><span style="font-family: arial, helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">inhibits NF-&kappa;B-mediated gene transcription in cells by blocking the phosphorylation and degradation of I&kappa;B&alpha;. </span><span style="font-family: arial, helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">Wedelolactone has no effects on p38 MAP kinase or Akt.</span></p>


Catalog Number R006650
CAS Number 524-12-9
Synonyms

1,8,9-trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one

Molecular Formula C16H10O7
Purity ≥95%
Target IκB/IKK
IUPAC Name 1,8,9-trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one
InChI InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
InChIKey XQDCKJKKMFWXGB-UHFFFAOYSA-N
SMILES COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O
Reference

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<span style="font-size:12px;"><span style="orphans: 2; widows: 2;">1.</span><span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">Kobori, M., et al. 2004.&nbsp;</span><i style="caret-color: rgb(68, 68, 68); color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">Cell Death Differ.</i><span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">&nbsp;</span><b style="caret-color: rgb(68, 68, 68); color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">11,</b><span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">&nbsp;123.</span></span></div>
<span style="font-size:12px;"><span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">2.Li, C.C., et al. 2003.&nbsp;</span><i style="caret-color: rgb(68, 68, 68); color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">J. Org. Chem.</i><span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">&nbsp;</span><b style="caret-color: rgb(68, 68, 68); color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">68,</b><span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">&nbsp;8500.</span><br style="caret-color: rgb(68, 68, 68); color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;" />
<span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">3.Mors, W.B., et al. 1989.&nbsp;</span><i style="caret-color: rgb(68, 68, 68); color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">Toxicon</i><span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">&nbsp;</span><b style="caret-color: rgb(68, 68, 68); color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">27,</b><span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">&nbsp;1003.</span><br style="caret-color: rgb(68, 68, 68); color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;" />
<span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">4.Wagner, H., and Fessler, B. 1986.&nbsp;</span><i style="caret-color: rgb(68, 68, 68); color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">Planta Med.</i><span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">&nbsp;</span><b style="caret-color: rgb(68, 68, 68); color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">5,</b><span style="caret-color: rgb(68, 68, 68); font-family: arial, helvetica, sans-serif; orphans: 2; widows: 2;">&nbsp;374.</span></span>

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