WEE1-IN-5（Cat No.:I043530）is a potent inhibitor of the WEE1 kinase, an enzyme that regulates the cell cycle by inhibiting the activation of cyclin-dependent kinases (CDKs) during DNA damage and replication stress. By blocking WEE1, WEE1-IN-5 forces cells to prematurely enter mitosis, even in the presence of DNA damage, leading to increased DNA fragmentation and cell death. This compound shows potential in enhancing the efficacy of chemotherapy and radiation therapy, particularly in tumors with compromised DNA repair mechanisms, such as certain cancers. Its ability to target cell cycle regulation makes it a promising therapeutic agent in oncology.