WEHI-345

• CAT Number: I001372
• CAS Number: 1354825-58-3
• Molecular Formula: C22H23N7O
• Molecular Weight: 401.46
• Purity: ≥95%
• Target: RIPK2
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: Store at -20°C
• IC50: 0.13 μM
• IUPAC Name: N-[2-[4-amino-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]pyridine-4-carboxamide
• InChI: InChI=1S/C22H23N7O/c1-14-4-6-15(7-5-14)18-17-19(23)26-13-27-20(17)29(28-18)22(2,3)12-25-21(30)16-8-10-24-11-9-16/h4-11,13H,12H2,1-3H3,(H,25,30)(H2,23,26,27)
• InChIKey: LEBSTCDZKUSVOY-UHFFFAOYSA-N
• SMILES: O=C(NCC(C)(N1N=C(C2=CC=C(C)C=C2)C3=C(N)N=CN=C31)C)C4=CC=NC=C4

WEHI-345（Cat No.:I001372） is a highly potent and selective inhibitor of receptor-interacting protein kinase 2 (RIPK2). It exhibits an inhibitory activity with an IC50 value of 0.13 μM against RIPK2, a kinase involved in the regulation of immune and inflammatory responses. By targeting RIPK2, WEHI-345 has the potential to modulate immune signaling pathways and mitigate inflammatory diseases.

Reference

[1]. Nachbur U, et al. A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production. Nat Commun. 2015 Mar 17;6:6442.