WEHI-539 hydrochloride

• CAT Number: I005764
• CAS Number: 2070018-33-4
• Molecular Formula: C31H30ClN5O3S2
• Molecular Weight: 620.18
• Purity: ≥95%
• Synonyms: (E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid
• Target: Bcl-2 Family
• Solubility: 10 mM in DMSO
• Storage: Store at -20℃
• IC50: 1.1 nM (BCL-XL)
• IUPAC Name: 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid;hydrochloride
• InChI: 1S/C31H29N5O3S2.ClH/c32-18-19-10-14-22(15-11-19)39-16-4-9-27-28(30(37)38)34-29(40-27)21-13-12-20-5-3-7-24(23(20)17-21)35-36-31-33-25-6-1-2-8-26(25)41-31;/h1-2,6,8,10-15,17H,3-5,7,9,16,18,32H2,(H,33,36)(H,37,38);1H/b35-24+
• InChIKey: GJBYTVIQTMIXGA-DYICZVFTSA-N
• SMILES: C1CC2=C(C=C(C=C2)C3=NC(=C(S3)CCCOC4=CC=C(C=C4)CN)C(=O)O)/C(=N/NC5=NC6=CC=CC=C6S5)/C1.Cl

WEHI-539 hydrochloride(CAT: I005764) is a highly selective and potent inhibitor of BCL-XL, a member of the BCL-2 family of anti-apoptotic proteins. By specifically targeting BCL-XL, WEHI-539 promotes apoptosis in cancer cells reliant on this protein for survival. It is widely used in research to explore the mechanisms of programmed cell death and to investigate therapeutic strategies for cancers with dysregulated apoptosis pathways. WEHI-539 hydrochloride is a critical tool for advancing oncology studies and the development of targeted anti-cancer therapies.