WEHI-539

• CAT Number: I001669
• CAS Number: 1431866-33-9
• Molecular Formula: C31H29N5O3S2
• Molecular Weight: 620.18
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: C1CC2=C(C=C(C=C2)C3=NC(=C(S3)CCCOC4=CC=C(C=C4)CN)C(=O)O)C(=NNC5=NC6=CC=CC=C6S5)C1.Cl

WEHI-539 has high affinity (IC50=1.1 nM) and selectivity for BCL-XL and potently kills cells by selectively antagonizing its prosurvival activity. It has more than a 400-fold higher affinity for BCL-XL versus other prosurvival BCL-2 family members.

Reference

[1] Lessene G, et al. Nat Chem Biol, 2013, 9(6), 390-397.