WH-4-023

• CAT Number: I005016
• CAS Number: 837422-57-8
• Molecular Formula: C32H36N6O4
• Molecular Weight: 568.678
• Purity: ≥95%
• Synonyms: 2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate
• Target: Src
• Solubility: DMSO: ≥ 46.8 mg/mL
• Storage: Desiccate at -20C
• IC50: 2 nM/6 nM(Lck/Src) [1]
• IUPAC Name: (2,6-dimethylphenyl) N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]carbamate
• InChI: InChI=1S/C32H36N6O4/c1-22-7-6-8-23(2)30(22)42-32(39)38(27-14-13-26(40-4)21-28(27)41-5)29-15-16-33-31(35-29)34-24-9-11-25(12-10-24)37-19-17-36(3)18-20-37/h6-16,21H,17-20H2,1-5H3,(H,33,34,35)
• InChIKey: NBTNHSGBRGTFJS-UHFFFAOYSA-N
• SMILES: CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C

WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.IC50 value: 2 nM/6 nM(Lck/Src) [1]Target: Lck/Src inhibitor

Reference

[1]. Martin MW, et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91.