WHI-P131

• CAT Number: I002558
• CAS Number: 202475-60-3
• Molecular Formula: C₁₆H₁₅N₃O₃
• Molecular Weight: 297.31
• Purity: ≥95%
• Synonyms: 4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
• Target: JAK
• Solubility: DMSO：≥ 3 mg/mL
• Storage: Store at -20°C
• IC50: 78 uM (JAK3)[1]
• InChI: InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-3-5-11(20)6-4-10/h3-9,20H,1-2H3,(H,17,18,19)
• InChIKey: HOZUXBLMYUPGPZ-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)O)OC

WHI-P131（Cat No.:I002558）is a potent Janus kinase 3 (JAK3) inhibitor, known for its immunosuppressive properties. By selectively targeting JAK3, WHI-P131 blocks the JAK-STAT signaling pathway, crucial for the development and function of immune cells. This inhibition helps prevent immune cell proliferation and activity, making WHI-P131 a valuable candidate in research focused on autoimmune diseases and transplant rejection. Its specificity and effectiveness offer potential therapeutic benefits in conditions like rheumatoid arthritis, psoriasis, and other inflammatory disorders, providing a promising approach to modulate the immune response.