WHI-P180（Cat No.:I002628） is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively. WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses.
| Catalog Number | I002628 |
| CAS Number | 211555-08-7 |
| Synonyms | 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol |
| Molecular Formula | C16H15N3O3 |
| Purity | ≥95% |
| Target | Cyclin-Dependent Kinases |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20C |
| IC50 | 1 uM (Cdk2); 4 uM (EGFR) |
| IUPAC Name | 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol |
| InChI | InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19) |
| InChIKey | BNDYIYYKEIXHNK-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)O)OC |
| Reference | <p style=/line-height:25px/> <br>[2]. Chen CL, et al. Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice. Pharm Res. 1999 Jan;16(1):117-22. </p> |
