WHI-P258

• CAT Number: I010080
• CAS Number: 21561-09-1
• Molecular Formula: C16H15N3O2
• Molecular Weight: 281.32
• Purity: ≥95%
• Synonyms: WHI-P258; WHI-P 258; WHI-P-258; WHIP 258.;6,7-Dimethoxy-N-phenylquinazolin-4-amine
• Target: JNK
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 6,7-dimethoxy-N-phenylquinazolin-4-amine
• InChI: InChI=1S/C16H15N3O2/c1-20-14-8-12-13(9-15(14)21-2)17-10-18-16(12)19-11-6-4-3-5-7-11/h3-10H,1-2H3,(H,17,18,19)
• InChIKey: MJKCGAHOCZLYDG-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC=C3)OC

WHI-P258 (Cat No.:I010080) is a potent inhibitor of Janus kinase 3 (JAK3), a key enzyme involved in intracellular signaling pathways. By specifically targeting JAK3, WHI-P258 interferes with the signaling cascade mediated by this kinase, which plays a crucial role in immune responses and cellular proliferation. The inhibition of JAK3 by WHI-P258 may hold therapeutic potential for various conditions, including acute lymphoblastic leukemia (ALL), a prevalent type of childhood cancer. Through its ability to disrupt JAK3-dependent signaling, WHI-P258 offers a promising avenue for the development of novel treatment strategies aimed at combating ALL and other diseases characterized by dysregulated JAK3-mediated pathways.

Reference

1:Sudbeck EA, Liu XP, Narla RK, Mahajan S, Ghosh S, Mao C, Uckun FM. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. PubMed PMID: 10389946.