Win 18446

• CAT Number: R042704
• CAS Number: 1477-57-2
• Molecular Formula: C12H20Cl4N2O2
• Molecular Weight: 366.10
• Purity: ≥95%
• Synonyms: N,N’-1,8-Octanediylbis[2,2-dichloroacetamide; Bis-Diamine; Fertilysin; Fertilysine; N,N’-Bis(dichloroacetyl)-1,8-diaminooctane; N,N’-Bis(dichloroacetyl)-1,8-octamethylenediamine; N,N’-Octamethylenebis(2,2-dichloroacetamide); NSC 59354; Win 18441
• Target: Aldehyde Dehydrogenase (ALDH)
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4C
• IUPAC Name: 2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide
• InChI: InChI=1S/C12H20Cl4N2O2/c13-9(14)11(19)17-7-5-3-1-2-4-6-8-18-12(20)10(15)16/h9-10H,1-8H2,(H,17,19)(H,18,20)
• InChIKey: FAOMZVDZARKPFJ-UHFFFAOYSA-N
• SMILES: C(CCCCNC(=O)C(Cl)Cl)CCCNC(=O)C(Cl)Cl

WIN 18446（Cat No.:R042704）is a nonsteroidal compound that selectively inhibits aldehyde dehydrogenase 1A1 (ALDH1A1), an enzyme critical for retinoic acid biosynthesis. By blocking ALDH1A1, WIN 18446 reduces retinoic acid production, impacting processes like cell differentiation, proliferation, and spermatogenesis. Its effects on retinoid metabolism have made it a valuable tool in reproductive biology and cancer research, particularly in exploring retinoic acid’s role in stem cell maintenance and tumor growth. WIN 18446 is being investigated for its potential applications in male contraception and retinoid pathway modulation in cancer treatment.