For research use only. Not for therapeutic Use.
Withaferin A (CAT: I011847) is a natural bioactive compound derived from the Withania somnifera plant, commonly known as ashwagandha. It is classified as a withanolide and possesses a wide range of pharmacological activities. Withaferin A has been extensively studied for its anticancer properties, exhibiting cytotoxic effects against various cancer cells by inducing apoptosis, inhibiting cell proliferation, and suppressing tumor growth. It also exhibits anti-inflammatory, immunomodulatory, and antioxidant activities. Withaferin A has shown potential therapeutic applications in the treatment of cancer, neurodegenerative diseases, inflammation, and other conditions.
| Catalog Number | I011847 |
| CAS Number | 5119-48-2 |
| Synonyms | Deuterated (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid δ-Lactone; Deuterated (20S,22R)-5,6β-Epoxy-4β,22,27-trihydroxy-1-oxo-5β-ergosta-?2,24-dien-26-oic Acid δ-Lactone; Deuterated NSC 101088; Deuterated NSC 273757; |
| Molecular Formula | C28H38O6 |
| Purity | ≥95% |
| Target | NF-κB |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | -20°C |
| IUPAC Name | (1S,2R,6S,7R,9R,11S,12S,15R,16S)-6-hydroxy-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one |
| InChI | InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1 |
| InChIKey | DBRXOUCRJQVYJQ-CKNDUULBSA-N |
| SMILES | CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)C=CC6O)C)O5)C)CO |
| Reference | 1: Yan X, Huang G, Liu Q, Zheng J, Chen H, Huang Q, Chen J, Huang H. Withaferin A protects against spinal cord injury by inhibiting apoptosis and inflammation in mice. Pharm Biol. 2017 Dec;55(1):1171-1176. doi: 10.1080/13880209.2017.1288262. PubMed PMID: 28228044.<br /> |
