Withanolide A

• CAT Number: R020844
• CAS Number: 32911-62-9
• Molecular Formula: C28H38O6
• Molecular Weight: 470.606
• Purity: ≥95%
• Synonyms: (5α,6α,7α,22R)-6,7-epoxy-5,20,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic Acid δ-Lactone; (22R)-6α,7α-epoxy-5,20,22-trihydroxy-1-oxo-5α-Ergosta-2,24-dien-26-oic Acid δ-Lactone; 6,7-Epoxy-1H-cyclopenta[a]phenanthrene Ergosta-2,24-dien-26-oic Acid Der
• Target: Stem Cell/Wnt
• Storage: -20°C
• InChI: InChI=1S/C28H38O6/c1-14-13-20(33-24(30)15(14)2)27(5,31)18-9-8-16-21-17(10-12-25(16,18)3)26(4)19(29)7-6-11-28(26,32)23-22(21)34-23/h6-7,16-18,20-23,31-32H,8-13H2,1-5H3/t16-,17-,18-,20+,21-,22-,23-,25-,26-,27+,28-/m0/s1
• InChIKey: DXWHOKCXBGLTMQ-SFQAJKIESA-N
• SMILES: CC1=C(C(=O)OC(C1)C(C)(C2CCC3C2(CCC4C3C5C(O5)C6(C4(C(=O)C=CC6)C)O)C)O)C

Withanolide A is a natural product isolated from the medicinal plant W. somnifera that has antioxidant and neuroprotective activity. It helps to promote neurite outgrowth at 1 µM in cultured neurons and in rodents injected with Aβ(25-35), and also recovers Aβ(25-35)-induced memory deficit in mice (10 µmol/kg/day). Withanolide A reverses hypoxia-mediated neurodegeneration by restoring hypoxia-induced glutathione depletion in the hippocampus of mice.