WN1316

• CAT Number: I038311
• CAS Number: 1356959-71-1
• Molecular Formula: C20H26Cl3N5O
• Molecular Weight: 458.81
• Purity: 98%
• Synonyms: WN1316; WN-1316; WN 1316
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-[Mesityl(methyl)amino]-N-[4-(pyridin-2-yl)-1H-imidazol-2-yl] acetamide trihydrochloride
• InChI: InChI=1S/C20H23N5O.3ClH/c1-13-9-14(2)19(15(3)10-13)25(4)12-18(26)24-20-22-11-17(23-20)16-7-5-6-8-21-16;;;/h5-11H,12H2,1-4H3,(H2,22,23,24,26);3*1H
• InChIKey: XZNHUZDSSZMVLD-UHFFFAOYSA-N
• SMILES: O=C(NC1=NC(C2=NC=CC=C2)=CN1)CN(C3=C(C)C=C(C)C=C3C)C.[H]Cl.[H]Cl.[H]Cl

WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS).

Reference

1: Kanno T, Yasutake K, Tanaka K, Hadano S, Ikeda JE. A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection. PLoS One. 2017 Oct 9;12(10):e0186227. doi: 10.1371/journal.pone.0186227. eCollection 2017. PubMed PMID: 29016670; PubMed Central PMCID: PMC5633190.
2: Tanaka K, Kanno T, Yanagisawa Y, Yasutake K, Inoue S, Hirayama N, Ikeda JE. A novel acylaminoimidazole derivative, WN1316, alleviates disease progression via suppression of glial inflammation in ALS mouse model. PLoS One. 2014 Jan 31;9(1):e87728. doi: 10.1371/journal.pone.0087728. eCollection 2014. PubMed PMID: 24498180; PubMed Central PMCID: PMC3909264.