WNK-IN-3

• CAT Number: I038313
• CAS Number: 853298-47-2
• Molecular Formula: C27H32F3N7O2
• Molecular Weight: 543.59
• Purity: 98%
• Synonyms: WNK-IN-3; WNK IN 3; WNKIN3
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1-[4-(4-Isopropyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-3-[4-(2-methylamino-pyrimidin-4-yloxy)-phenyl]-urea
• InChI: InChI=1S/C27H32F3N7O2/c1-18(2)37-14-12-36(13-15-37)17-19-4-5-21(16-23(19)27(28,29)30)34-26(38)33-20-6-8-22(9-7-20)39-24-10-11-32-25(31-3)35-24/h4-11,16,18H,12-15,17H2,1-3H3,(H,31,32,35)(H2,33,34,38)
• InChIKey: TZKBNGYRAFKRJC-UHFFFAOYSA-N
• SMILES: O=C(NC1=CC=C(OC2=NC(NC)=NC=C2)C=C1)NC3=CC=C(CN4CCN(C(C)C)CC4)C(C(F)(F)F)=C3

WNK-IN-3(CAT: I038313) is a highly selective and potent inhibitor of WNK (With-No-Lysine [K]) kinases, crucial regulators of ion transport and homeostasis. It is widely employed in research focused on elucidating WNK signaling pathways, particularly their role in hypertension, electrolyte balance, and related disorders. By inhibiting WNK kinases, WNK-IN-3 aids in studying mechanisms underlying disorders such as pseudohypoaldosteronism type II (PHAII). With excellent selectivity and reliable performance, this compound serves as a valuable tool for preclinical studies and the development of novel therapies targeting WNK-mediated pathways.