For research use only. Not for therapeutic Use.
WNK1-IN-1 is a selective inhibitor of WNK1 with an IC50 value of 1.6 μM. WNK1-IN-1 inhibits OSR1 phosphorylation with an IC50 value of 4.3 μM. WNK1-IN-1 can be used for the research of blood pressure regulation and cancer[1].
WNK1-IN-1 (0-1000 μM; 30 min) shows high potency to WNK1 with an IC50 value of 1.6 μM[1].
WNK1-IN-1 (0.2-12.5 μM; 24 h) inhibits endogenous OSR1 phosphorylation with an IC50 value of 4.3 μM in MDAMB231 breast-cancer cells[1].
WNK1-IN-1 (0-100 mM) is 10-fold more potent to WNK1 than WNK3 in Kinase-Glo assay[1].
| Catalog Number | I042607 |
| CAS Number | 324022-39-1 |
| Synonyms | 4-[bromo(dichloro)methyl]sulfonyl-N-cyclohexyl-2-nitroaniline |
| Molecular Formula | C13H15BrCl2N2O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C13H15BrCl2N2O4S/c14-13(15,16)23(21,22)10-6-7-11(12(8-10)18(19)20)17-9-4-2-1-3-5-9/h6-9,17H,1-5H2 |
| InChIKey | REBZZEDLLSTDTN-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)NC2=C(C=C(C=C2)S(=O)(=O)C(Cl)(Cl)Br)[N+](=O)[O-] |
| Reference | [1]. Rodriguez M, et al. Synthesis and Structural Characterization of Novel Trihalo-sulfone Inhibitors of WNK1. ACS Med Chem Lett. 2022 Sep 23;13(10):1678-1684. |
