Wnt/β-catenin agonist 1

• CAT Number: I046206
• CAS Number: 2305372-67-0
• Molecular Formula: C22H25N3O2
• Molecular Weight: 363.45
• Purity: ≥95%
• Synonyms: 8-[(2,5-dimethylpyrazol-3-yl)methoxy]-5-ethyl-4-methyl-6H-phenanthridin-9-ol
• InChI: InChI=1S/C22H25N3O2/c1-5-25-12-16-10-21(27-13-17-9-15(3)23-24(17)4)20(26)11-19(16)18-8-6-7-14(2)22(18)25/h6-11,26H,5,12-13H2,1-4H3
• InChIKey: YXSHAOWUACPIQX-UHFFFAOYSA-N
• SMILES: CCN1CC2=CC(=C(C=C2C3=CC=CC(=C31)C)O)OCC4=CC(=NN4C)C

Wnt/β-catenin agonist 1 (compound 3f) is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM[1].
EC50: 0.27 μM (Wnt/β-catenin)[1].

Reference

[1]. Chen DZ, et al. Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/β-catenin signalling pathway agonists. Bioorg Chem. 2019 Mar;84:285-294.
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