Wnt pathway inhibitor 3

• CAT Number: I041131
• CAS Number: 663213-98-7
• Molecular Formula: C21H17BrN2O5
• Molecular Weight: 457.27
• Purity: ≥95%
• Synonyms: 6-amino-8-(3-bromo-5-methoxy-4-prop-2-enoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene-7-carbonitrile
• InChI: InChI=1S/C21H17BrN2O5/c1-3-4-26-20-14(22)5-11(6-18(20)25-2)19-12-7-16-17(28-10-27-16)8-15(12)29-21(24)13(19)9-23/h3,5-8,19H,1,4,10,24H2,2H3
• InChIKey: OUSQIRTYEYYEHZ-UHFFFAOYSA-N
• SMILES: COC1=C(C(=CC(=C1)C2C3=CC4=C(C=C3OC(=C2C#N)N)OCO4)Br)OCC=C

Wnt pathway inhibitor 3 is a potent wnt inhibitor with an IC50 value of 45 nM. Wnt pathway inhibitor 3 shows antiproliferative activity[1].
Wnt pathway inhibitor 3 (compound 41) (0-100 000nM; 72 h) shows antiproliferative activity with IC50s of 641, 470, 551, 618 nM for HS68, Dld1, HCT116, SW480 cells, respectively[1].

Reference

[1]. Michael Boutros, et al. Chromene derivatives and their analoga as wnt pathway antagonists. US20130296344A1.