WQ 1

• CAT Number: I038321
• CAS Number: 1204401-49-9
• Molecular Formula: C21H23NOS
• Molecular Weight: 337.481
• Purity: 98%
• Synonyms: WQ 1; WQ1; WQ-1; TC WQ 1; TCWQ 1; TC-WQ 1; TC WQ1; TC WQ-1; TCWQ1; TC-WQ-1; TC Sigma1; TC-Sigma1; TC Sigma-1; TC Sigma 1
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(1-benzylpiperidin-4-yl)thiochroman-4-one
• InChI: InChI=1S/C21H23NOS/c23-19-14-21(24-20-9-5-4-8-18(19)20)17-10-12-22(13-11-17)15-16-6-2-1-3-7-16/h1-9,17,21H,10-15H2
• InChIKey: XWMHOCDNGHEUMF-UHFFFAOYSA-N
• SMILES: O=C1C2=CC=CC=C2SC(C3CCN(CC3)CC4=CC=CC=C4)C1

WQ 1(CAT: I038321) represents a significant advancement in the field of pharmaceutical and neurobehavioral research. As a high affinity and selective antagonist of the σ1 receptor, this compound holds promise in modulating behavior and addressing specific neuropsychiatric conditions. Its remarkable σ1/σ2 selectivity ratio of 29512 underscores its specificity for the σ1 receptor subtype. Of note, WQ 1’s ability to selectively block binge eating without general inhibition of food intake in rats suggests potential applications in treating eating disorders.