For research use only. Not for therapeutic Use.
(WRK)4 is a novel Antimicrobial Peptide with Repeating Unit against Multidrug-Resistant Bacteria.
| Catalog Number | I038332 |
| Synonyms | (WRK)4; (WRK) 4; (WRK)-4; |
| Molecular Formula | C92H139N33O12 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (S)-2-((6S,9S,12S,15S)-12-((1H-indol-3-yl)methyl)-1-amino-6-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-9-(4-aminobutyl)-15-(3-guanidinopropyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-amido)-N-((2S,5S,8S,11S,14S,17S)-11-((1H-indol-3-yl)methyl)-21-amino-8-(4-aminobutyl)-17-carbamoyl-5,14-bis(3-guanidinopropyl)-1-(1H-indol-3-yl)-3,6,9,12,15-pentaoxo-4,7,10,13,16-pentaazahenicosan-2-yl)-6-aminohexanamide |
| InChI | InChI=1S/C92H139N33O12/c93-37-13-9-29-66(77(98)126)115-79(128)71(34-18-42-108-90(101)102)120-86(135)74(46-54-50-112-63-26-6-2-22-58(54)63)123-84(133)68(31-11-15-39-95)118-81(130)73(36-20-44-110-92(105)106)122-88(137)76(48-56-52-114-65-28-8-4-24-60(56)65)125-85(134)69(32-12-16-40-96)119-82(131)72(35-19-43-109-91(103)104)121-87(136)75(47-55-51-113-64-27-7-3-23-59(55)64)124-83(132)67(30-10-14-38-94)117-80(129)70(33-17-41-107-89(99)100)116-78(127)61(97)45-53-49-111-62-25-5-1-21-57(53)62/h1-8,21-28,49-52,61,66-76,111-114H,9-20,29-48,93-97H2,(H2,98,126)(H,115,128)(H,116,127)(H,117,129)(H,118,130)(H,119,131)(H,120,135)(H,121,136)(H,122,137)(H,123,133)(H,124,132)(H,125,134)(H4,99,100,107)(H4,101,102,108)(H4,103,104,109)(H4,105,106,110)/t61-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-/m0/s1 |
| InChIKey | FZNHAQVJFVYBNX-XRMNIVIASA-N |
| SMILES | O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC7=CNC8=CC=CC=C78)N |
| Reference | 1: Zhong C, Zhang F, Yao J, Zhu Y, Zhu N, Zhang J, Ouyang X, Zhang T, Li B, Xie J, Ni J. New Antimicrobial Peptides with Repeating Unit against Multidrug- Resistant Bacteria. ACS Infect Dis. 2021 Apr 8. doi: 10.1021/acsinfecdis.0c00797. Epub ahead of print. PMID: 33829758. |
