For research use only. Not for therapeutic Use.
WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer. WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells[1].
WRR139 (0.01-100 μM; 1 h) inhibits NGLY1 in vitro and impairs processing of Nrf1 in HEK293 cells[1].
WRR139 (5 μM; 18 h) disrupts Nrf1 processing, location, and activation in HEK293 cells[1].
WRR139 (1 μM; 24 h) enhances the cytotoxicity of Carfilzomib in an NGLY1-dependent manner in U266, H929, and Jurkat cells[1].
| Catalog Number | I041808 |
| CAS Number | 2138924-36-2 |
| Synonyms | (2S)-N-(3-methylbutyl)-2-[[(E)-3-(4-methylphenyl)sulfonylprop-2-enoyl]amino]-4-phenylbutanamide |
| Molecular Formula | C25H32N2O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C25H32N2O4S/c1-19(2)15-17-26-25(29)23(14-11-21-7-5-4-6-8-21)27-24(28)16-18-32(30,31)22-12-9-20(3)10-13-22/h4-10,12-13,16,18-19,23H,11,14-15,17H2,1-3H3,(H,26,29)(H,27,28)/b18-16+/t23-/m0/s1 |
| InChIKey | BLEQGDOEDLJWCG-NGIFANIDSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)C=CC(=O)NC(CCC2=CC=CC=C2)C(=O)NCCC(C)C |
| Reference | [1]. Tomlin FM, et al. Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity. ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. |
