WRVYEKC(dnp)ALK tetraTFA

• CAT Number: I041331
• Molecular Formula: C74H100F12N18O26S
• Molecular Weight: 1917.74
• Purity: ≥95%
• Synonyms: (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-3-(2,4-dinitrophenyl)sulfanylpropanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C66H96N18O18S.4C2HF3O2/c1-35(2)29-49(61(93)78-48(65(97)98)16-9-11-27-68)79-56(88)37(5)74-63(95)51(34-103-53-24-20-40(83(99)100)32-52(53)84(101)102)81-58(90)45(15-8-10-26-67)76-59(91)47(23-25-54(86)87)77-62(94)50(30-38-18-21-41(85)22-19-38)80-64(96)55(36(3)4)82-60(92)46(17-12-28-72-66(70)71)75-57(89)43(69)31-39-33-73-44-14-7-6-13-42(39)44;4*3-2(4,5)1(6)7/h6-7,13-14,18-22,24,32-33,35-37,43,45-51,55,73,85H,8-12,15-17,23,25-31,34,67-69H2,1-5H3,(H,74,95)(H,75,89)(H,76,91)(H,77,94)(H,78,93)(H,79,88)(H,80,96)(H,81,90)(H,82,92)(H,86,87)(H,97,98)(H4,70,71,72);4*(H,6,7)/t37-,43-,45-,46-,47-,48-,49-,50-,51-,55-;;;;/m0..../s1
• InChIKey: UAZKVTVFJCOIJN-ZDFQTMBPSA-N
• SMILES: CC(C)CC(C(=O)NC(CCCCN)C(=O)O)NC(=O)C(C)NC(=O)C(CSC1=C(C=C(C=C1)[N+](=O)[O-])[N+](=O)[O-])NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC3=CNC4=CC=CC=C43)N.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

WRVYEKC(dnp)ALK tetraTFA contains tryptophan that can be liberated from the dinitrophenol (DNP) quencher by aminopeptidase activity. WRVYEKC(dnp)ALK tetraTFA can be used as a hydrolysis reaction decapeptide substrate[1].

Reference

[1]. Nguyen TT, et al. Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol. 2011 May;18(5):604-13.