For research use only. Not for therapeutic Use.
WS-12(CAT: I010086) holds a distinctive role as a potent activator of the transient receptor potential melastatin 8 (TRPM8) channel. Operating as a TRPM8 agonist, WS-12 exhibits a unique cooling sensation when applied to the skin or mucous membranes. This cooling effect is attributed to its ability to stimulate the TRPM8 channel, which is known to be sensitive to cold temperatures. By activating TRPM8, WS-12 triggers a perception of cooling that can be harnessed for various sensory and therapeutic applications.
| Catalog Number | I010086 |
| CAS Number | 68489-09-8 |
| Synonyms | WS 12; WS-12; WS12.;(1R,2S)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide |
| Molecular Formula | C18H27NO2 |
| Purity | ≥95% |
| Target | TRP Channel |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at -20C |
| Reference | </br>1:Development of a 12-Item Abbreviated Three-Dimensional Wisdom Scale (3D-WS-12): Item Selection and Psychometric Properties. Thomas ML, Bangen KJ, Ardelt M, Jeste DV.Assessment. 2017 Jan;24(1):71-82. Epub 2015 Jul 24. PMID: 26209513 </br>2:Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Ma S, G G, Ak VE, Jf D, H H.Pak J Pharm Sci. 2008 Oct;21(4):370-8. PMID: 18930858 |
