For research use only. Not for therapeutic Use.
WS-383 effectively blocks interaction between DCN1 and UBC12 (IC50 value of 11 nM), causes selective Cul3/1 neddylation inhibition over other cullins, and induces accumulation of p21, p27, and NRF2.
KEYWORDS: WS-383 | supplier | DCN1-UBC12 inhibitor | DCN1-UBC12 interaction inhibitor E31 | WS383 | WS 383 | CAS [2247543-65-1] | [2247544-02-9] | Non Selective (Ubiquitin peptides) | Ubiquitin-conjugating enzyme (E2) | Inhibitor | Enzymes | UBE2M | UBC12 | DCN1 | NEDD8 | CRL
| Catalog Number | I017135 |
| CAS Number | 2247543-65-1 |
| Molecular Formula | C18H20ClN9S2 |
| Purity | ≥95% |
| IUPAC Name | 2-[5-[[2-[(4-chlorophenyl)methylsulfanyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]sulfanyl]tetrazol-1-yl]-N,N-dimethylethanamine |
| InChI | InChI=1S/C18H20ClN9S2/c1-12-10-15(30-18-22-24-25-27(18)9-8-26(2)3)28-16(20-12)21-17(23-28)29-11-13-4-6-14(19)7-5-13/h4-7,10H,8-9,11H2,1-3H3 |
| SMILES | CC1=NC2=NC(=NN2C(=C1)SC3=NN=NN3CCN(C)C)SCC4=CC=C(C=C4)Cl |
| Reference | S Wang et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2019 Mar 14;62(5):2772-2797. |
