For research use only. Not for therapeutic Use.
WS3（Cat No.:I001617） is a proliferative molecule that promotes pancreatic β cell proliferation in murine and human primary islets. WS3 can be used in the research of type 1 diabetes. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.
| Catalog Number | I001617 |
| CAS Number | 1421227-52-2 |
| Synonyms | N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide |
| Molecular Formula | C28H30F3N7O3 |
| Purity | ≥95% |
| Target | TRP Channel |
| Solubility | DMSO: ≥ 43 mg/mL |
| Storage | Sealed in dry,2-8°C |
| IUPAC Name | N-[6-[4-[[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyrimidin-4-yl]cyclopropanecarboxamide |
| InChI | InChI=1S/C28H30F3N7O3/c1-37-10-12-38(13-11-37)16-19-4-5-21(14-23(19)28(29,30)31)35-27(40)34-20-6-8-22(9-7-20)41-25-15-24(32-17-33-25)36-26(39)18-2-3-18/h4-9,14-15,17-18H,2-3,10-13,16H2,1H3,(H2,34,35,40)(H,32,33,36,39) |
| InChIKey | KIKOYRNAERIVSJ-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC=NC(=C4)NC(=O)C5CC5)C(F)(F)F |
| Reference | </br>1:Electrosynthesis of bifunctional WS3-x/rGO hybrid for HER and ORR electrocatalysis. Pumera M.Chemistry. 2017 Apr 27. doi: 10.1002/chem.201701722. [Epub ahead of print] PMID: 28449325 </br>2:Global Distribution Patterns and Pangenomic Diversity of the Candidate Phylum /Latescibacteria/ (WS3). Farag IF, Youssef NH, Elshahed MS.Appl Environ Microbiol. 2017 May 1;83(10). pii: e00521-17. doi: 10.1128/AEM.00521-17. Print 2017 May 15. PMID: 28314726 </br>3:Bottom-up Electrosynthesis of Highly Active Tungsten Sulfide (WS3-x) Films for Hydrogen Evolution. Tan SM, Pumera M.ACS Appl Mater Interfaces. 2016 Feb 17;8(6):3948-57. doi: 10.1021/acsami.5b11109. Epub 2016 Feb 4. PMID: 26844594 </br>4:In Silico Analysis of the Metabolic Potential and Niche Specialization of Candidate Phylum /Latescibacteria/ (WS3). Youssef NH, Farag IF, Rinke C, Hallam SJ, Woyke T, Elshahed MS.PLoS One. 2015 Jun 3;10(6):e0127499. doi: 10.1371/journal.pone.0127499. eCollection 2015. PMID: 26039074 Free PMC Article</br>5:Solvent effect-driven assembly of W/Cu/S cluster-based coordination polymers from the cluster precursor [Et4N][Tp*WS3(CuBr)3] and CuCN: isolation, structures and enhanced NLO responses. Liu Q, Ren ZG, Deng L, Zhang WH, Zhao X, Sun ZR, Lang JP.Dalton Trans. 2015 Jan 7;44(1):130-7. doi: 10.1039/c4dt02725f. PMID: 25353691 </br>6:Six [Tp*WS3Cu2]-based clusters derived from [Et4N][Tp*WS3], Cu(I) salts and phosphine ligands: syntheses, structures and enhanced third-order NLO properties. Zhou LK, Liu Q, Zhao X, Hu FL, Liu SC, Ren ZG, Sun ZR, Lang JP.Dalton Trans. 2014 Mar 28;43(12):4734-44. doi: 10.1039/c3dt53320d. PMID: 24473639 </br>7:Construction of [(eta5-C5Me5)WS3Cu3]-based supramolecular compounds from preformed incomplete cubane-like clusters [PPh4][(eta5-C5Me5)WS3(CuX)3] (X = CN, Br). Xu QF, Chen JX, Zhang WH, Ren ZG, Li HX, Zhang Y, Lang JP.Inorg Chem. 2006 May 15;45(10):4055-64. PMID: 16676966 </br>8:Assembly of a supramolecular cube, [(Cp*WS3Cu3)8 Cl8(CN)12Li4] from a preformed incomplete cubane-like compound [PPh4][Cp*WS3(CuCN)3]. Lang JP, Xu QF, Chen ZN, Abrahams BF.J Am Chem Soc. 2003 Oct 22;125(42):12682-3. PMID: 14558796 </br>9:Expression of senescence-induced protein WS3-10 in vivo and in vitro. Grigoriev VG, Thweatt R, Moerman EJ, Goldstein S.Exp Gerontol. 1996 Jan-Apr;31(1-2):145-57. PMID: 8706785 |
