WTX-101

• CAT Number: I010088
• CAS Number: 649749-10-0
• Molecular Formula: C10H28MoN2O2S4
• Molecular Weight: 432.54
• Purity: ≥95%
• Synonyms: WTX-101; ATN-224; WTX101; ATN224; WTX 101; ATN 224;2-hydroxy-N,N,N-trimethylethan-1-aminium tetrathiomolybdate
• Target: cytosolic superoxide dismutase (SOD1) inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: bis(sulfanylidene)molybdenum;2-hydroxyethyl(trimethyl)azanium;sulfanide
• InChI: InChI=1S/2C5H14NO.Mo.4S/c2*1-6(2,3)4-5-7;;;;;/h2*7H,4-5H2,1-3H3;;;;;/q2*+1;;;;2*-1
• InChIKey: NEYVHGQOGHJAAD-UHFFFAOYSA-N
• SMILES: S=[Mo]([S-])([S-])=S.OCC[N+](C)(C)C.OCC[N+](C)(C)C

WTX-101(CAT: I010088), also known as ATN-224, is a cytosolic superoxide dismutase (SOD1) inhibitor with potential applications in the treatment of Wilson’s disease. By inhibiting SOD1, WTX-101 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells and human diffuse large B cell lymphoma cell lines. Notably, its effects are independent of Bcl-2 and Bcl-xL proteins. WTX-101’s inhibitory action on SOD1 provides a novel approach for addressing oxidative stress-related conditions, such as Wilson’s disease, and further research is being conducted to explore its therapeutic potential.

Overview of Clinical Research

WTX-101 is a chelating agent. It has been granted for the orphan drug status in Hepatolenticular degeneration and Amyotrophic lateral sclerosis. 

Reference

1.Donate, F., et al. "Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)." British journal of cancer 98.4 (2008): 776-783.
2.Lee, Kristy, et al. "The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies." Free Radical Biology and Medicine 60 (2013): 157-167.