For research use only. Not for therapeutic Use.
WUN29654 is a CRBN modulator, which showed CRBN modulatory activity with IC50 value of 2.6μM, Ki value of 0.7μM and cell proliferation IC50 vale of ~21.53μM. WUN29654 was reported in patent WO 2020006262 (compound II). This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
| Catalog Number | I038350 |
| CAS Number | 2407829-65-4 |
| Synonyms | WUN29654; WUN-29654; WUN 29654; |
| Molecular Formula | C17H12N2O5 |
| Purity | 98% |
| Target | Ligands for E3 Ligase |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-(2,6-dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione |
| InChI | InChI=1S/C17H12N2O5/c20-9-6-8-2-1-3-10-14(8)11(7-9)17(24)19(16(10)23)12-4-5-13(21)18-15(12)22/h1-3,6-7,12,20H,4-5H2,(H,18,21,22) |
| InChIKey | WGTKYDFLBDSIPX-UHFFFAOYSA-N |
| SMILES | O=C(C1=C2C(C=C(O)C=C23)=CC=C1)N(C4CCC(NC4=O)=O)C3=O |
| Reference | Gray, Nathanael; Zhang, Tinghu; Fischer, Eric; Verano, Alyssa; He, Zhixiang; Du, Guangyan; Donovan, Katherine; Nowak, Radoslaw; Yuan, Christine. 2-(2,6-Dioxopiperidin-3-yl)benzo[de]isoquinoline-1,3(2H)-diones as CRBN modulators and their preparation. PCT Int. Appl. (2020), WO 2020006262. |
