For research use only. Not for therapeutic Use.
WX-132-18B is a microtubule-depolymerizing agent that selectively acts on the colchicine-binding site of tubulin and exerts potent in vitro and in vivo anti-tumor effects. Specifically, WX-132-18B exhibited high in vitro cytotoxic activity (GI50 value of 1.9–3.2 nM), significant potency against tubulin assembly (IC50 value of 0.77 μM), and substantial inhibition of colchicine binding (99% at 5 μM). Moreover, WX-132-18B caused cell arrest in G2/M phase.
KEYWORDS: WX-132-18B | Supplier | Microtubule inhibitor | WX132-18B | WX 132-18B | CAS [1415262-07-5] | Cytoskeleton | Tubulin | Inhibitor | Proteins | Colchicine | G2/M phase
| Catalog Number | I047630 |
| CAS Number | 1415262-07-5 |
| Molecular Formula | C18H16N4O2 |
| Purity | ≥95% |
| IUPAC Name | 7-methoxy-4-(2-methylquinazolin-4-yl)-1,3-dihydroquinoxalin-2-one |
| InChI | InChI=1S/C18H16N4O2/c1-11-19-14-6-4-3-5-13(14)18(20-11)22-10-17(23)21-15-9-12(24-2)7-8-16(15)22/h3-9H,10H2,1-2H3,(H,21,23) |
| SMILES | CC1=NC2=CC=CC=C2C(=N1)N3CC(=O)NC4=C3C=CC(=C4)OC |
| Reference | XF Wang et al. Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site. J Med Chem. 2014 Feb 27;57(4):1390-402.
F Guan et al. WX-132-18B, a novel microtubule inhibitor, exhibits promising anti-tumor effects. Oncotarget. 2017 May 9;8(42):71782-71796. |
