WX-554(CAT: I009772) is an orally bioavailable small-molecule inhibitor targeting mitogen-activated protein kinase kinase (MEK), a pivotal component of the RAS/RAF/MEK/ERK signaling pathway. By selectively binding to MEK, WX-554 inhibits its kinase activity, thereby blocking the phosphorylation and activation of downstream effector proteins, including key transcription factors. This mechanism disrupts growth factor-mediated cell signaling, leading to reduced tumor cell proliferation. As MEK is often upregulated in various cancers, WX-554 is a valuable tool for investigating targeted therapies in oncology. Its high specificity and effectiveness make it ideal for preclinical research, supporting the development of novel antineoplastic strategies.
| Catalog Number | I009772 |
| Synonyms | ;NONE |
| Purity | ≥95% |
| Target | MEK inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
