WYC-209

• CAT Number: I019016
• CAS Number: 2131803-90-0
• Molecular Formula: C₂₀H₂₀N₂O₃S
• Molecular Weight: 368.45
• Purity: ≥95%
• IUPAC Name: ethyl 2-[2-(4,4-dimethyl-1-oxo-2,3-dihydrothiochromen-6-yl)ethynyl]pyrimidine-5-carboxylate
• InChI: InChI=1S/C20H20N2O3S/c1-4-25-19(23)15-12-21-18(22-13-15)8-6-14-5-7-17-16(11-14)20(2,3)9-10-26(17)24/h5,7,11-13H,4,9-10H2,1-3H3
• InChIKey: LLMDAYVUHYVJSS-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=CN=C(N=C1)C#CC2=CC3=C(C=C2)S(=O)CCC3(C)C

WYC-209 (Cat No.:I019016) is a synthetic retinoid and a potent agonist of retinoic acid receptors (RARs). It exhibits pharmacological activity by inducing apoptosis primarily through the caspase 3 pathway. WYC-209 demonstrates significant inhibitory effects on the growth of tumor cells, including malignant murine melanoma TRCs (tumor-repopulating cells), with an IC50 of 0.19 μM. Moreover, WYC-209 has long-term effects with minimal toxicity. In experimental models, WYC-209 has shown the ability to inhibit tumor growth and metastasis, making it a promising candidate for the development of anticancer therapies. In animal studies, WYC-209 administration effectively inhibits tumor metastasis in mice bearing lung metastases. These findings highlight the potential of WYC-209 as a therapeutic agent for the treatment of cancer.

Reference

[1]. Chen J, et al. Inhibition of cancer stem cell like cells by a synthetic retinoid. Nat Commun. 2018 Apr 11;9(1):1406.