For research use only. Not for therapeutic Use.
A tissue selective liver X receptor (LXR) agonist; WYE672 showed potent binding affinity to LXRβ (IC50 = 53 nM), it had little binding affinity for LXRα (IC50 >1.0 μM)
| Catalog Number | I047585 |
| CAS Number | 1221265-37-7 |
| Molecular Formula | C23H17F3N2O2S |
| Purity | ≥95% |
| IUPAC Name | 3-methyl-2-[4-(3-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)quinoxaline |
| InChI | InChI=1S/C23H17F3N2O2S/c1-14-21(28-20-8-4-7-19(22(20)27-14)23(24,25)26)16-11-9-15(10-12-16)17-5-3-6-18(13-17)31(2,29)30/h3-13H,1-2H3 |
| SMILES | CC1=NC2=C(C=CC=C2N=C1C3=CC=C(C=C3)C4=CC(=CC=C4)S(=O)(=O)C)C(F)(F)F |
| Reference | B Hu et al. Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist. J. Med. Chem. 2010, 53(8), 3296-3304.
T Jakobsson et al. Liver X receptor biology and pharmacology: new pathways, challenges and opportunities. Trends Pharmacol Sci. 2012, 33(7), 394-404. |
