WZ811

• CAT Number: I004079
• CAS Number: 55778-02-4
• Molecular Formula: C18H18N4
• Molecular Weight: 290.4
• Purity: ≥95%
• Synonyms: N-[[4-[(pyridin-2-ylamino)methyl]phenyl]methyl]pyridin-2-amine
• Target: CXCR
• Solubility: DMSO 25 mg/ml; Water <1 mg/mL
• Storage: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• IC50: 0.3 nM(EC50)
• InChI: InChI=1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)
• InChIKey: KBVFRXIGQQRMEF-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)NCC2=CC=C(C=C2)CNC3=CC=CC=N3

WZ811 (Cat No.:I004079) is a potent and competitive CXCR4 antagonist with EC50 of 0.3 nM. WZ811 effectively counteracts the reduction of cAMP by SDF-1 at doses as low as several nanomolar. WZ811 inhibits SDF-1-mediated invasion with EC50 of 5.2 nM. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Zhan W, Liang Z, Zhu A, et al. Discovery of small molecule CXCR4 antagonists. J Med Chem. 2007;50(23):5655-64.
[2]. Lavrovsky, Yan; Ivanenkov, Yan A.; Balakin, Konstantin V, et al. CXCR4 Receptor as a Promising Target for Oncolytic Drugs. Mini Rev Med Chem. 2008 Oct;8(11):1075-87.
[3]. Zhu A, Zhan W, Liang Z, et al. Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity. J Med Chem. 2010,23;53(24):8556-68.
[4]. Kawatkar SP, Yan M, Gevariya H, et al. Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists. Exp Biol Med (Maywood). 2011;236(7):844-50.