Xanthine oxidase, Microorganism

• CAT Number: I042550
• CAS Number: 9002-17-9
• Purity: ≥95%

Xanthine oxidase, Microorganism (XO) is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid[1].
Xanthine oxidase rapidly and completely depletes hypoxanthine in human erythrocytes[2].
Xanthine oxidase (20 mU/mL, 72 h) inhibits growth of Plasmodium falciparum in human erythrocytes[2].
Xanthine oxidase (0.02 U/mL, 6 h) reduces the viability of postnatal cerebellar granule neurons obtained from 8-day old Sprague-Dawley rat pups[3].

Reference

[1]. AdeebShehzad, et al. Chapter Eight – Curcumin: A Potent Modulator of Multiple Enzymes in Multiple Cancers.

[2]. Berman PA, et al. Xanthine oxidase inhibits growth of Plasmodium falciparum in human erythrocytes in vitro. J Clin Invest. 1991 Dec;88(6):1848-55.
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[3]. Fatokun AA, et al. Hydrogen peroxide mediates damage by xanthine and xanthine oxidase in cerebellar granule neuronal cultures. Neurosci Lett. 2007 Apr 6;416(1):34-8.
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