For research use only. Not for therapeutic Use.
Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.
Xanthotoxol (62.5-250 μM; 20 min) reduces the production of inflammatory factors induced by LPS stimulation in a concentration-dependent manner and inhibits LPS-induced p65 translocation from the cytoplasm to the nucleus in RAW 264.7 cells[3].
Xanthotoxol (5 mg/kg, 10 mg/kg; ip; 2 dose) can attenuate the expression of pro-inflammatory mediators in the ischemia/reperfusion (I/R) rat model, thereby inhibiting the inflammatory response after cerebral ischemia[4].
| Catalog Number | R053744 |
| CAS Number | 2009-24-7 |
| Synonyms | 9-hydroxyfuro[3,2-g]chromen-7-one |
| Molecular Formula | C11H6O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H6O4/c12-8-2-1-6-5-7-3-4-14-10(7)9(13)11(6)15-8/h1-5,13H |
| InChIKey | JWVYQQGERKEAHW-UHFFFAOYSA-N |
| SMILES | C1=CC(=O)OC2=C(C3=C(C=CO3)C=C21)O |
| Reference | [1]. Ma Z, et al. Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509. |
