For research use only. Not for therapeutic Use.
XAV939 is a small molecule and selective Wnt pathway β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively.
Catalog Number | I002965 |
CAS Number | 284028-89-3 |
Synonyms | 2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one |
Molecular Formula | C₁₄H₁₁F₃N₂OS |
Purity | ≥95% |
Target | PARP |
Solubility | DMSO: ≤ 21.5 mg/mL |
Storage | 3 years -20C powder |
IC50 | 11 nM(TNKS1); 4 nM(TNKS2) |
InChI | InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20) |
InChIKey | KLGQSVMIPOVQAX-UHFFFAOYSA-N |
SMILES | C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F |
Reference | <p> |