For research use only. Not for therapeutic Use.
BET bromodomain inhibitor (K<sub>d</sub> values are 160, 170, 380, 490, 830 and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2) respectively). Also inhibits BRDT(1), CBP, p300 and BRDT(2) (K<sub>d</sub> values are 1.2, 1.6, 2.6 and 3.7 <span class=/’symbol/’>μ</span>M respectively). Attenuates proliferation of HL-60 leukemia cells <em>in vitro</em>.
| Catalog Number | I011216 |
| CAS Number | 1370888-71-3 |
| Synonyms | 4-Acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide |
| Molecular Formula | C20H27N3O5S |
| Purity | ≥95% |
| Target | Epigenetic Reader Domain |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Storage | Store at -20C |
| IUPAC Name | 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide |
| InChI | InChI=1S/C20H27N3O5S/c1-6-15-18(13(5)24)12(4)21-19(15)20(26)22-16-11-14(9-10-17(16)25)29(27,28)23(7-2)8-3/h9-11,21,25H,6-8H2,1-5H3,(H,22,26) |
| InChIKey | DPBKLIVPNYGQQG-UHFFFAOYSA-N |
| SMILES | CCC1=C(NC(=C1C(=O)C)C)C(=O)NC2=C(C=CC(=C2)S(=O)(=O)N(CC)CC)O |
