XE 991 dihydrochloride

• CAT Number: I010491
• CAS Number: 122955-13-9
• Molecular Formula: C26H22Cl2N2O
• Molecular Weight: 449.37
• Purity: ≥95%
• Synonyms: 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
• Target: Potassium Channel
• Solubility: Soluble to 100 mM in water
• Storage: Store at -20°C
• IUPAC Name: 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride
• InChI: InChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H
• InChIKey: WOGWMARIFDNZON-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl

XE 991 dihydrochloride（Cat No.: I010491）, is a potent blocker of Kv7 (KCNQ) channels, effectively inhibiting multiple subtypes of these voltage-gated potassium channels. It exhibits notable inhibitory activity with IC50 values of 0.75 µM for Kv7.1 (KCNQ1), 0.71 µM for Kv7.2 (KCNQ2), 0.6 µM for the Kv7.2 + Kv7.3 heteromeric channel (KCNQ3), and 0.98 µM for the M-current. These characteristics make XE 991 dihydrochloride a valuable tool in research related to Kv7 channel function and regulation, with potential implications for understanding their role in neuronal excitability and the development of therapeutic interventions.