For research use only. Not for therapeutic Use.
KCNQ channel and M-current blocker; potential AD therapeutic. The hydrochloride salt of XE 991 (Axon 1305) is available as well.
| Catalog Number | M024121 |
| CAS Number | 122955-42-4 |
| Molecular Formula | C26H20N2O |
| Purity | ≥95% |
| IUPAC Name | 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one;dihydrochloride |
| InChI | InChI=1S/C26H20N2O.2ClH/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25;;/h1-16H,17-18H2;2*1H |
| SMILES | C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl |
| Reference | Wang et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 1998, 282 1890.
Zaczek et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl) -9(10H)-anthracenone: comparison to linopirdine. J. Pharmacol. Exp. Ther. 1998, 285 724. |
