XESTOSPONGIN C

• CAT Number: I010173
• CAS Number: 88903-69-9
• Molecular Formula: C28H50N2O2
• Molecular Weight: 446.71
• Purity: ≥95%
• Synonyms: ARGUSPONGINE E;[1R-(1R*,4AR*,11R*,12AS*,13S*,16AS*,23R*,24AS*)]-EICOSAHYDRO-5H,17H-1,23:11,13-DIETHANO-2H,14H-[1,11]DIOXACYCLOEICOSINO[2,3-B:12,13-B/’]DIPYRIDINE;XESTOSPONGIN C;XEC;XESTOSPONGIN;(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1
• Target: Neuronal Signaling
• Solubility: Soluble to 2 mM in DMSO and to 2 mM in ethanol
• Storage: Desiccate at -20 ℃
• IUPAC Name: (1R,8R,10S,15S,22R,29S)-9,30-dioxa-11,25-diazapentacyclo[20.6.2.28,11.010,15.025,29]dotriacontane
• InChI: 1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1
• InChIKey: PQYOPBRFUUEHRC-HCKQMYSWSA-N
• SMILES: [H][C@@]1(N2CCC3)[C@H]3CCCCCC[C@H]4O[C@]5([H])N(CCC[C@H]5CCCCCC[C@H](CC2)O1)CC4

Xestospongin C (CAT: I010173) is a naturally occurring marine compound derived from the marine sponge Xestospongia exigua. It is a potent and selective inhibitor of inositol trisphosphate (IP3) receptor channels. Xestospongin C specifically targets the IP3 receptor, which is a calcium release channel located on the endoplasmic reticulum membrane. By inhibiting the IP3 receptor, Xestospongin C blocks the release of calcium from the endoplasmic reticulum, thereby affecting various calcium-dependent cellular processes. Xestospongin C has been widely used as a pharmacological tool to investigate the role of IP3 receptors in cellular signaling pathways. Its application extends to studying calcium-mediated events such as neurotransmission, cell proliferation, apoptosis, and intracellular calcium homeostasis.