For research use only. Not for therapeutic Use.
XL-147（Cat No.:I005671）is a potent and selective inhibitor of class I phosphoinositide 3-kinase (PI3K), a critical component of the PI3K/AKT signaling pathway involved in cell growth, proliferation, and survival. By targeting PI3K, XL-147 disrupts these processes, making it valuable in cancer research, particularly in tumors with dysregulated PI3K signaling. It has been studied for its potential to inhibit tumor growth in various cancers, including breast, ovarian, and non-small cell lung cancers. XL-147 is also explored in combination with other therapies to enhance treatment efficacy and overcome resistance.
| Catalog Number | I005671 |
| CAS Number | 956958-53-5 |
| Synonyms | N-[3-(2,1,3-benzothiadiazol-5-ylamino)quinoxalin-2-yl]-4-methylbenzenesulfonamide |
| Molecular Formula | C₂₁H₁₆N₆O₂S₂ |
| Purity | ≥95% |
| Target | PI3K |
| Solubility | DMSO ≥86mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| Storage | 3 years -20℃ powder |
| IUPAC Name | N-[3-(2,1,3-benzothiadiazol-5-ylamino)quinoxalin-2-yl]-4-methylbenzenesulfonamide |
| InChI | InChI=1S/C21H16N6O2S2/c1-13-6-9-15(10-7-13)31(28,29)27-21-20(23-16-4-2-3-5-17(16)24-21)22-14-8-11-18-19(12-14)26-30-25-18/h2-12H,1H3,(H,22,23)(H,24,27) |
| InChIKey | MQMKRQLTIWPEDM-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4 |
| Reference | <p> |
