XL-647

• CAT Number: I004870
• CAS Number: 781613-23-8
• Molecular Formula: C24H25Cl2FN4O2
• Molecular Weight: 491.39
• Purity: ≥95%
• Target: Protein Tyrosine Kinase/RTK
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: 3 years -20C powder

XL647 (Cat.No:I004870) is an orally bioavailable small-molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity; inhibits EGFR, HER2, VEGFR and EphB4 kinase.

Reference

[1]. Doebele RC, et al. New strategies to overcome limitations of reversible EGFR tyrosine kinase inhibitor therapy in non-small cell lung cancer. Lung Cancer. 2010 Jul;69(1):1-12.