For research use only. Not for therapeutic Use.
XL413 Hydrochloride（Cat No.:I020705）is a potent and selective inhibitor of CDC7, a kinase essential for initiating DNA replication in eukaryotic cells. By inhibiting CDC7, XL413 disrupts DNA replication, leading to cell cycle arrest and apoptosis, making it a valuable tool for cancer research. Its specificity for CDC7 enables detailed studies on the role of DNA replication in cancer progression. XL413 Hydrochloride is widely used in drug development and research related to cancer therapeutics, offering insights into novel anti-cancer strategies by targeting replication stress pathways.
| Catalog Number | I020705 |
| CAS Number | 2062200-97-7 |
| Molecular Formula | C₁₄H₁₃Cl₂N₃O₂ |
| Purity | ≥95% |
| Reference | [1]. Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31.<br>[2]. Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300. |
