XQN70430

• CAT Number: I038447
• CAS Number: 1638970-43-0
• Molecular Formula: C46H50N6O8
• Molecular Weight: 814.94
• Purity: 98%
• Synonyms: MC-​Ala-​Ala-​Asn(Trt)​-​PAB; XQN70430; XQN-70430; XQN 70430
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (S)-2-((S)-2-((S)-2-(7-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)heptanamido)propanamido)propanamido)-N1-(4-hydroxyphenyl)-N4-tritylsuccinamide
• InChI: InChI=1S/C46H50N6O8/c1-31(47-39(54)22-14-3-4-15-29-52-41(56)27-28-42(52)57)43(58)48-32(2)44(59)50-38(45(60)49-36-23-25-37(53)26-24-36)30-40(55)51-46(33-16-8-5-9-17-33,34-18-10-6-11-19-34)35-20-12-7-13-21-35/h5-13,16-21,23-28,31-32,38,53H,3-4,14-15,22,29-30H2,1-2H3,(H,47,54)(H,48,58)(H,49,60)(H,50,59)(H,51,55)/t31-,32-,38-/m0/s1
• InChIKey: XFPHUWWFIUTOLG-QXGWMLRCSA-N
• SMILES: O=C(C[C@H](NC([C@@H](NC([C@@H](NC(CCCCCCN1C(C=CC1=O)=O)=O)C)=O)C)=O)C(NC2=CC=C(C=C2)O)=O)NC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5

XQN70430(CAT: I038447) (also known as MC-Ala-Ala-Asn(Trt)-PAB) is a heterobifunctional cross-linker designed for use in antibody-drug conjugation (ADC). It features a reactive maleimide group for site-specific conjugation with thiol groups on antibodies and a cleavable para-aminobenzyl (PAB) spacer for controlled drug release. The Ala-Ala-Asn(Trt) sequence serves as a protective and linker moiety, enabling precise attachment of cytotoxic payloads to targeting antibodies. XQN70430 plays a critical role in the development of ADCs, facilitating the delivery of therapeutic agents to specific cells, such as tumor cells, while minimizing off-target effects. Its versatility and efficacy make it a valuable tool in ADC technology and targeted drug delivery research.