XRK3F2

• CAT Number: I019712
• CAS Number: 2375193-43-2
• Molecular Formula: C₂₃H₂₄ClF₂NO₃
• Molecular Weight: 435.89
• Purity: ≥95%
• Target: Autophagy
• Storage: Store at -20°C
• IUPAC Name: 2-[[3,4-bis[(4-fluorophenyl)methoxy]phenyl]methylamino]ethanol;hydrochloride
• InChI: InChI=1S/C23H23F2NO3.ClH/c24-20-6-1-17(2-7-20)15-28-22-10-5-19(14-26-11-12-27)13-23(22)29-16-18-3-8-21(25)9-4-18;/h1-10,13,26-27H,11-12,14-16H2;1H
• InChIKey: OKFZPRHMUQRCLJ-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1COC2=C(C=C(C=C2)CNCCO)OCC3=CC=C(C=C3)F)F.Cl

XRK3F2 (Cat No.: I019712) is a p62-ZZ inhibitor that has demonstrated efficacy in multiple myeloma (MM) research. In vitro, it counteracts MM-induced Runx2 inhibition, a transcription factor associated with bone formation. In vivo, XRK3F2 has been shown to induce new bone formation and remodeling in the presence of tumors. This dual action makes it a promising candidate for MM therapy and addressing bone-related complications in cancer patients. Researchers interested in XRK3F2 or seeking additional information can contact us for prompt assistance.

Reference

[1]. Adamik J, et al. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. Front Endocrinol (Lausanne). 2018 Jun 29;9:344.