XX-650-23

• CAT Number: I038465
• CAS Number: 117739-40-9
• Molecular Formula: C18H12N2O2
• Molecular Weight: 288.30
• Purity: ≥95%
• Synonyms: N-(4-cyanophenyl)-3-hydroxynaphthalene-2-carboxamide
• InChI: InChI=1S/C18H12N2O2/c19-11-12-5-7-15(8-6-12)20-18(22)16-9-13-3-1-2-4-14(13)10-17(16)21/h1-10,21H,(H,20,22)
• InChIKey: DRBIYQSSEMTUJQ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC=C(C=C3)C#N)O

XX-650-23 is a potent CREB inhibitor. XX-650-23inhibits CREB function through disruption of CBP-CREB interaction. XX-650-23 can be used for AML research[1].
XX-650-23 (870 nM-2.3 μM; 48 hours) inhibits AML cell growth, the IC50 values are 870 nM, 910 nM, 2.0 μM and 2.3 μM for HL-60, KG-1, MOLM-13, and MV-4-11,respectively[1].
XX-650-23( 5 μM; 6 or 24 hours) causes a specific decrease in H3K27 acetylation and is not a general inhibitor of acetyltransferase activity[1].
XX-650-23 (2 μM; 72 hours) elicits apoptosis through the intrinsic apoptosis pathway, with activation of caspase-3 and detectable caspase-9 cleavage. It also leads to the downregulation of Mcl-1 and bcl-2[1].

Reference

[1]. B Mitton, et al. Small molecule inhibition of cAMP response element binding protein in human acute myeloid leukemia cells. Leukemia. 2016 Dec;30(12):2302-2311.
 [Content Brief]