For research use only. Not for therapeutic Use.
XY1（Cat No.: I002090）, functions as an inactive analog of SGC707 and serves as a useful negative control for SGC707 in research experiments. SGC707, on the other hand, is a highly potent and selective allosteric inhibitor specifically targeting protein arginine methyltransferase 3 (PRMT3). It displays impressive inhibitory activity, with IC50 and Kd values of 31nM and 53nM, respectively, against PRMT3. This precision in inhibition makes SGC707 a valuable tool for investigating the cellular functions of PRMT3 and exploring its potential as a therapeutic target in various biological contexts.
| Catalog Number | I002090 |
| CAS Number | 1624117-53-8 |
| Synonyms | N-2-naphthalenyl-N/’-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea |
| Molecular Formula | C17H19N3O2 |
| Purity | ≥95% |
| Target | Histone Methyltransferase |
| Solubility | 10 mM in DMSO |
| Storage | -20°C |
| IUPAC Name | 1-naphthalen-2-yl-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea |
| InChI | InChI=1S/C17H19N3O2/c21-16(20-9-3-4-10-20)12-18-17(22)19-15-8-7-13-5-1-2-6-14(13)11-15/h1-2,5-8,11H,3-4,9-10,12H2,(H2,18,19,22) |
| InChIKey | GSQHGSRPQHBTTP-UHFFFAOYSA-N |
| SMILES | C1CCN(C1)C(=O)CNC(=O)NC2=CC3=CC=CC=C3C=C2 |
| Reference | </br>1:The 34,XY1,der(13) chromosome constitution with loss of Y2 is associated with unilateral testicular hypoplasia in the endangered Indian blackbuck antelope (Antilope cervicapra). Sontakke SD, Kandukuri LR, Umapathy G, Kulashekaran KM, Venkata PO, Shivaji S, Singh L.Sex Dev. 2012;6(5):240-6. doi: 10.1159/000339898. Epub 2012 Jul 26. PMID: 22846804 </br>2:Continuous wave and passively Q-switched Nd:Lu xY1-x VO4 laser at 1.34 μm with V3+:YAG as the saturable absorber. Zhang S, Huang H, Xu L, Wang M, Chen F, Xu J, He J, Zhao B.Opt Express. 2011 Jan 31;19(3):1830-5. doi: 10.1364/OE.19.001830. PMID: 21368997 </br>3:SNP typing of the reference materials SRM 2391b 1-10, K562, XY1, XX74, and 007 with the SNPforID multiplex. Børsting C, Tomas C, Morling N.Forensic Sci Int Genet. 2011 Jun;5(3):e81-2. doi: 10.1016/j.fsigen.2010.07.004. Epub 2010 Aug 17. No abstract available. PMID: 20724236 |
