Xylometazoline free base

• CAT Number: I038478
• CAS Number: 526-36-3
• Molecular Formula: C16H24N2
• Molecular Weight: 244.38
• Purity: 98%
• Synonyms: Xylometazoline free base, BA 11391; BA-11391; BA11391
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
• InChI: InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18)
• InChIKey: HUCJFAOMUPXHDK-UHFFFAOYSA-N
• SMILES: CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1

Xylometazoline(CAT: I038478) is an imidazole-derived nasal decongestant commonly used to alleviate symptoms of nasal congestion, allergic rhinitis, and sinusitis. It acts as a sympathomimetic agent by binding to α1 and α2 adrenergic receptors in the nasal mucosa, causing vasoconstriction and reducing swelling. Designed to mimic the molecular shape of adrenaline, Xylometazoline provides rapid relief by improving airflow through the nasal passages. However, its use is recommended for no longer than seven days to avoid rebound congestion (rhinitis medicamentosa). Due to its systemic sympathomimetic effects, it is contraindicated in individuals with high blood pressure or heart conditions. Xylometazoline is a widely studied agent in respiratory and cardiovascular research, particularly for its role in adrenergic receptor pharmacology.