Y 26611

• CAT Number: I038515
• CAS Number: 143375-60-4
• Molecular Formula: C18H19F2N3O4
• Molecular Weight: 379.3638
• Purity: 98%
• Synonyms: Y 26611; Y-26611; Y26611.
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Y 26611
• InChI: InChI=1S/C18H19F2N3O4/c19-13-5-11-15(14(20)16(13)22-3-4-27-10(6-21)7-22)23(9-1-2-9)8-12(17(11)24)18(25)26/h5,8-10H,1-4,6-7,21H2,(H,25,26)
• InChIKey: MVKGRIHKSLEKTE-UHFFFAOYSA-N
• SMILES: c1c2c(c(c(c1F)N3CCOC(C3)CN)F)n(cc(c2=O)C(=O)O)C4CC4

Y 26611 is a biochemical.

Reference

1: Sakurai N, Sano M, Hirayama F, Kuroda T, Uemori S, Moriguchi A, Yamamoto K, Ikeda Y, Kawakita T. Synthesis and structure-activity relationships of 7-(2-aminoalkyl)morpholinoquinolones as anti-Helicobacter pylori agents. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2185-90. Erratum in: Bioorg Med Chem Lett 1998 Oct 20;8(20):2937. PubMed PMID: 9873510.
2: Akter U, Niwa M, Nose T, Kaida T, Matsuno H, Kozawa O, Uematsu T. Effects of several agents on UVB- and UVA plus systemic fluoroquinolone-induced erythema of guinea pig skin evaluated by reflectance colorimetry. Free Radic Biol Med. 1998 May;24(7-8):1113-9. PubMed PMID: 9626565.
3: Wada K, Saniabadi AR, Umemura K, Nakano M, Ito T, Nakashima M. Direct measurement of superoxide-dependent chemiluminescence from rat skin following UV-dependent fluoroquinolone-induced dermatitis. Free Radic Biol Med. 1995 May;18(5):923-7. PubMed PMID: 7797102.
4: Kubo S, Matsumoto T, Takahashi K, Haraoka M, Tanaka M, Sakumoto M, Sakamoto Y, Kumazawa J. Enhanced chemiluminescence response of polymorphonuclear leukocytes by new quinolone antimicrobials. Chemotherapy. 1994 Sep-Oct;40(5):333-6. PubMed PMID: 7956457.
5: Wada K, Saniabadi AR, Umemura K, Takiguchi Y, Nakashima M. UV-dependent quinolone-induced human erythrocyte membrane lipid peroxidation: studies on the phototoxicity of Y-26611, a new quinolone derivative. Pharmacol Toxicol. 1994 Apr-May;74(4-5):240-3. PubMed PMID: 8090693.
6: Araki K, Kuroda T, Uemori S, Moriguchi A, Ikeda Y, Hirayama F, Yokoyama Y, Iwao E, Yakushiji T. Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships. J Med Chem. 1993 May 14;36(10):1356-63. PubMed PMID: 8388467.
7: Tomioka H, Sato K, Saito H. [Antimicrobial activity of new quinolones against Mycobacterium avium and Mycobacterium intracellulare determined by the dilution methods using 7H11 agar and Ogawa egg media]. Kekkaku. 1993 May;68(5):367-70. Japanese. PubMed PMID: 8331881.
8: Tomioka H, Sato K, Saito H, Ikeda Y. [Antimycobacterial activity of a newly synthesized fluoroquinolone, Y-26611]. Kekkaku. 1992 Jul;67(7):515-20. Japanese. PubMed PMID: 1331603.