For research use only. Not for therapeutic Use.
Y-26763 is a K+ channel opener and active metabolite of Y-27152[1]. Y-26763 is an ATP-sensitive K+ (KATP) channel activator[2].
| Catalog Number | M115874 |
| CAS Number | 127408-31-5 |
| Synonyms | N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-hydroxyacetamide |
| Molecular Formula | C14H16N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H16N2O4/c1-8(17)16(19)12-10-6-9(7-15)4-5-11(10)20-14(2,3)13(12)18/h4-6,12-13,18-19H,1-3H3/t12-,13+/m1/s1 |
| InChIKey | IWTCFIIOUXJOOV-OLZOCXBDSA-N |
| SMILES | CC(=O)N(C1C(C(OC2=C1C=C(C=C2)C#N)(C)C)O)O |
| Reference | [1]. Itoh T, et al. Effects of a newly synthesized K+ channel opener, Y-26763, on noradrenaline-induced Ca2+ mobilization in smooth muscle of the rabbit mesenteric artery. Br J Pharmacol. 1994 Jan;111(1):165-72. [2]. Tran QTN, et al. The identification of naturally occurring labdane diterpenoid calcaratarin D as a potential anti-inflammatory agent. Eur J Med Chem. 2019 Jul 15;174:33-44. |
