For research use only. Not for therapeutic Use.
Y 29794 tosylate is an orally active, potent and specific prolyl endopeptidase (PPCE) inhibitor that is easily penetrable into the brain. Y-29794 tosylate selectively and competitively inhibited rat brain PPCE in a reversible manner with a Ki value of 0.95 nM. Moreover, Y 29794 tosylate exhibited potent inhibitory activity with an IC50 value of 3.0 nM for both brain crude extract and partially purified enzyme fraction.
KEYWORDS: Y 29794 tosylate | supplier | PPCE inhibitor | Y29794 tosylate | Y-29794 tosylate | CAS [143984-17-2] | [129184-48-1] | [146794-84-5] | Non Selective (Serine Peptide Bonds) | Prolyl endopeptidase | Inhibitor | Enzymes | Alzheimer’s disease
Catalog Number | I010114 |
CAS Number | 143984-17-2 |
Molecular Formula | C23H34N2OS2.C7H8O3S |
Purity | ≥95% |
IUPAC Name | [2-[8-(dimethylamino)octylsulfanyl]-6-propan-2-ylpyridin-3-yl]-thiophen-2-ylmethanone;4-methylbenzenesulfonic acid |
InChI | InChI=1S/C23H34N2OS2.C7H8O3S/c1-18(2)20-14-13-19(22(26)21-12-11-17-27-21)23(24-20)28-16-10-8-6-5-7-9-15-25(3)4;1-6-2-4-7(5-3-6)11(8,9)10/h11-14,17-18H,5-10,15-16H2,1-4H3;2-5H,1H3,(H,8,9,10) |
SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)C1=NC(=C(C=C1)C(=O)C2=CC=CS2)SCCCCCCCCN(C)C |
Reference | T Nakajima et al. Y-29794 – a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992 Jul 20;141(2):156-60. |