Y15

• CAT Number: I003589
• CAS Number: 4506-66-5
• Molecular Formula: C₆H₁₀N₄•4HCl
• Molecular Weight: 284.01
• Purity: ≥95%
• Synonyms: benzene-1,2,4,5-tetraamine tetrahydrochloride
• Target: FAK
• Solubility: H2O: ≥ 59 mg/mL
• Storage: Desiccate at RT
• IUPAC Name: benzene-1,2,4,5-tetramine;tetrahydrochloride
• InChI: InChI=1S/C6H10N4.4ClH/c7-3-1-4(8)6(10)2-5(3)9;;;;/h1-2H,7-10H2;4*1H
• InChIKey: BZDGCIJWPWHAOF-UHFFFAOYSA-N
• SMILES: C1=C(C(=CC(=C1N)N)N)N.Cl.Cl.Cl.Cl

Y15（Cat No.:I003589）is a specific small-molecule inhibitor of focal adhesion kinase (FAK), a key protein involved in cell migration, proliferation, and survival. By targeting FAK’s autophosphorylation site, Y15 disrupts signaling pathways critical for cancer cell growth and metastasis. It has shown promising potential in preclinical studies for reducing tumor growth, especially in cancers characterized by high FAK expression, such as breast and ovarian cancers. Y15’s ability to impair tumor invasion and angiogenesis makes it a valuable tool for cancer research, with ongoing studies exploring its therapeutic applications in oncology.

Reference

[1]. Hochwald SN, et al. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle. 2009 Aug;8(15):2435-43.
[2]. Zheng D, et al. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. Mol Carcinog. 2010 Feb;49(2):200-9.
[3]. Golubovskaya VM, et al. Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide. Mol Cancer Ther. 2013 Feb;12(2):162-72.